No wonder Honolulu is expensive; it's full of tourists, mostly Asian, buying up exclusive Chanel handbags and Rolex watches unavailable elsewhere. Of course, the beautiful beaches and natural surroundings are also a draw. Although the number of full-time residents is only 371,657, Honolulu continues to climb up the ranks of our list of the best places for cities and careers.

Average rent for a two bedroom, luxury condo in the city is $4,500. Even a fast-food hamburger--anything but a luxury--costs an average $5.89. New York is the only American city in the top 50 most expensive cities in the world.

The average driver spends 72 hours a year stuck in traffic delays and, as of July 21, the cost of a gallon of regular gas was $4.46. However, the 13-point drop in worldwide ranking, from 42 in 2007 to 55 in 2008, indicates that the city is getting less expensive.

Despite the dismal real estate market, Miami is still a pricey spot, mostly due to its vibrant nightlife, tourism and large consortium of creative professionals.

In the last 25 years, Silicon Valley has brought billions into San Francisco's economy. With that cash comes high-end housing, pricey restaurants and, of course, greater demand for everything. Demand might push up prices, but if you're a young professional with an Ivy League education, the higher costs are worthwhile. The number of highly rated companies in the area comes in second only to New York.